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Updated: Jul 4, 2025

Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines
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Published on: June 2, 2018

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3D基因组分析揭示了由复杂的结构变化引起的新型增强器劫持,这些变化驱动着基因过度表达

Katelyn L Mortenson, Courtney Dawes, Emily R Wilson

    bioRxiv : the preprint server for biology
    |February 8, 2024
    PubMed
    概括

    研究人员开发了高活性促进体相互作用 (HAPI) 分析,以检测癌症基因组中的增强器劫持. 这种3D基因组学方法通过非编码DNA识别瘤基因激活,揭示了新的治疗点.

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