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Updated: Jul 4, 2025

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
09:33

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Published on: August 25, 2023

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在POU2F-POU2AF转录因子驱动的恶性瘤中准mSWI/SNF复合体

Tongchen He1,2,3,4, Lanbo Xiao1,2,4, Yuanyuan Qiao1,2,5

  • 1Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.

bioRxiv : the preprint server for biology
|February 8, 2024
PubMed
概括

小细胞肺癌亚型SCLC-P和某些B细胞恶性瘤依赖于mSWI/SNF复合体. 用PROTAC降解剂准这个复合体在临床前模型中显示出治疗前景.

关键词:
在 IRF4 基础上,IRF4 是一个 IRF4 项目.在POU2AF1/2/3中使用.在POU2F3F3中.在SMARCA2/4/4中使用.mSWI/SNF复合体是一个复合体.多发性骨髓瘤是多发性骨髓瘤的一种.蛋白质溶解向的木乃伊 (PROTAC) 的研究.小细胞肺癌 (SCLC) 是一种癌症.

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