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怀孕相关的氧化应激和炎症与母亲神经元活动或记忆功能受损无关

Jessica L Bradshaw, E Nicole Wilson, Jennifer J Gardner

bioRxiv : the preprint server for biology

|February 8, 2024

概括

怀孕会增加母亲海马 (CA1) 中的氧化应激,影响神经可塑性. 虽然可以控制炎症,但氧化压力可能会影响怀孕期间和之后的认知功能.

科学领域:

神经科学是一个神经科学.
生殖生物学生殖生物学
生物化学生物化学

背景情况:

怀孕会诱导神经和行为可塑性,全身炎症和氧化应激.
在怀孕期间炎症和氧化应激对母亲神经可塑性的特定影响仍然在很大程度上是未知的.
对于认知至关重要的母体海马体CA1被研究,以保护其免受与怀孕相关的系统性变化.

结论:

孕产妇的海马体 (CA1) 在怀孕期间受到系统性炎症的保护,但易受周围产妇氧化应激的影响.
升高的周产期氧化应激,可能因妊娠并发症而加剧,可能会影响母亲的神经和行为可塑性.
这些发现强调了氧化应激管理在维持产前期母亲认知健康的关键作用.

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