胸壁在出生时对呼吸功能的影响 近期的羔羊
Cailin Diedericks1,2, Kelly J Crossley1,2, Indya M Davies1,2
1The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia.
Journal of applied physiology (Bethesda, Md. : 1985)
|February 8, 2024
概括
外部负压会改善新生儿的呼吸功能和出生后的氧气交换,而正压会影响新生儿的呼吸功能. 胸壁机制显著影响新生儿的呼吸结果.
科学领域:
- 新生儿生理学 新生儿生理学
- 呼吸机械学 呼吸机械
- 肺部医学 肺部医学
背景情况:
- 产后气道液体清除导致肺和胸壁膨胀.
- 胸壁机制对于出生后适应呼吸空气至关重要.
- 近期的羊羔可以作为研究新生儿呼吸过渡的模型.
研究的目的:
- 为了研究改变胸壁机制对近期羔羊的呼吸功能的影响.
- 为了确定不同的气道液体体积如何影响呼吸对外部胸部压力的呼吸反应.
- 评估正面和负面外部压力对天然气交换和合规性的影响.
主要方法:
- 近期的羔羊被分为控制 (正常液体) 和升高液体 (EL) 组.
- 在通风过程中,对胸壁施加外部正或负压.
- 测量包括胸壁合规性 (CCW),肺合规性 (CL) 和气泡动脉氧气差 (AaDO2).
主要成果:
- 外部负压扩大了胸壁,增加了肺部的顺应性,改善了氧气交换 (降低了 AaDO).
- 外部正压压缩了胸壁,降低了肺部的顺应性,并损害了氧气交换 (增加了AaDO).
- 这些效应在对照和EL羔羊中都被观察到,这表明施加的胸部压力具有重大影响.
结论:
- 外部胸部压力显著影响新生羔羊的呼吸功能和气体交换.
- 在呼吸困难的羊群中,施加大气下压力可以增强呼吸功能.
- 积极的外部压力会对新生儿的呼吸功能产生负面影响,这凸显了在复苏过程中考虑胸壁力量的重要性.
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