患有疼痛糖尿病外围神经病变的患者下肢神经减压的影响:糖尿病神经病变神经减压随机,观察组和安慰剂手术控制的临床试验
Shai M Rozen1, Gil I Wolfe2, Steven Vernino3
1Department of Plastic and Reconstructive Surgery, University of Texas Southwestern Medical Center, Dallas, TX.
Annals of surgery
|February 8, 2024
概括
神经减压可能会减少糖尿病外围神经病变 (DPN) 的疼痛,但需要进一步的研究来确认好处是否来自手术或安慰剂效应.
科学领域:
- 神经学 神经学
- 糖尿病学 糖尿病学
- 手术研究的研究.
背景情况:
- 糖尿病外围神经病变 (DPN) 缺乏有效的长期止痛治疗.
- 神经减压对DPN疼痛的有效性目前仍在争论中,需要进一步研究.
研究的目的:
- 评估神经减压对患有下肢疼痛DPN的患者疼痛的影响.
- 为了比较手术减压与观察和假手术的有效性.
主要方法:
- 一项双盲,随机对照试验与18-80岁的患者进行,患者患有疼痛性DPN,不耐医疗治疗.
- 参与者被随机分配到神经减压或观察 (2:1比率). 减压患者接受了一条腿的盲目手术,另一条腿的假手术.
- 疼痛评分 (利克特11分) 在干预后12个月和56个月被评估.
主要成果:
- 在12个月后,两组压力减轻组报告与对照组相比,疼痛明显降低 (P < 0.0001).
- 在56个月后,减压组与对照组的疼痛仍然显著减少 (P < 0.0001).
- 在56个月后,减压腿部的疼痛分数比假腿部更低 (P = 0.0002).
结论:
- 神经减压在DPN患者中与减少疼痛有联系.
- 该研究表明,潜在的安慰剂效应可能对观察到的疼痛减轻有显著的贡献,需要进一步调查手术减压的真正益处.
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