在临床前阿尔茨海默病试验中,种族和族裔群体之间的披露后痛苦
Marina Ritchie1,2, Christian R Salazar1, Daniel L Gillen1,3
1UC Irvine Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|February 8, 2024
概括
在临床前试验中,对阿尔茨海默病生物标志物披露的反应在种族和种族群体之间没有显著差异. 目前的披露方法被支持用于阿尔茨海默病研究.
科学领域:
- 神经学 神经学
- 心理学 心理学 心理学
- 临床试验 临床试验
背景情况:
- 了解患者对阿尔茨海默病 (AD) 生物标志物披露的反应对于临床前AD试验至关重要.
- 这些反应中的种族和民族差异尚未得到充分证实.
- 这项研究解决了对不同参与者反应清晰度的需求.
研究的目的:
- 调查是否对粉样蛋白生物标志物披露的反应在不同种族和种族群体中在认知不受损的个体中有所不同.
- 为了检查粉样蛋白状态对这些反应的潜在修改.
主要方法:
- 利用了来自无症状阿尔茨海默病研究中的抗粉样蛋白治疗的数据.
- 事件规模 (IES) 的分析影响得分在披露后24-72小时内.
- 采用线性回归来比较种族和种族群体的平均IES分数,考虑粉样蛋白状况.
主要成果:
- 没有发现种族和民族群体对披露的反应有显著差异.
- 虽然在统计学上并不显著,但粉样蛋白水平升高的个体在大多数群体中通常报告了更高的IES平均得分,但不包括西班牙裔/拉丁裔参与者.
- 粉样蛋白状况没有显著改变观察到的反应.
结论:
- 目前用于披露阿尔茨海默病生物标志物信息的方法适用于临床前阿尔茨海默病试验.
- 这些发现支持在AD研究中公平地在不同人群中应用披露协议.
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