美国艾滋病毒感染老年人的年龄相关痴呆症:一项建模研究
Emily P Hyle1,2,3,4, Nattanicha Wattananimitgul1, Shibani S Mukerji3,5
1Medical Practice Evaluation Center, Department of Medicine, Massachusetts General Hospital.
AIDS (London, England)
|February 8, 2024
概括
与一般人群相比,60岁以上的艾滋病毒感染者 (PWH) 面临与年龄相关的痴呆症 (AAD) 的风险更高,预期寿命更短. 早期干预和护理规划对于这个老龄化的人群至关重要.
科学领域:
- 老年学是一门学科.
- 传染性疾病 传染性疾病
- 神经学 神经学
背景情况:
- 越来越多的艾滋病毒感染者 (PWH) 正在衰老,美国有近40万55岁以上的人.
- PWH有较高的年龄相关痴呆症 (AAD) 风险,包括阿尔茨海默病和对认知障碍和痴呆症 (VCID) 的血管贡献.
研究的目的:
- 预测美国60岁及以上的PWH中AAD相关的累积发病率和死亡率.
- 为了比较PWH和普通人群之间的AAD风险和结果.
主要方法:
- 集成CEPAC和AgeD-Pol模型来模拟60岁男性和女性个体 (PWH和一般人口) 的队列.
- 估计的AAD发病率,AAD相关的死亡率,预期寿命和经质量调整的寿命年 (QALY).
- 对关键参数进行了敏感性和场景分析.
主要成果:
- 预计80岁时AAD发展:22.1%的男性和16.3%的女性感染艾滋病毒,相比之下,一般人群中男性的15.9%和女性的13.3%.
- 与一般人口相比,60岁PWH的预期寿命 (QALYs) 较低:男性为17.4年 (14.1QALYs),女性为16.8年 (13.4QALYs).
- AAD发病率对非艾滋病毒相关死亡率,艾滋病毒护理参与和AAD发病率最敏感.
结论:
- 预计与AAD相关的发病率,死亡率和生活质量数据可以指导卫生系统和政策制定者.
- 加强AAD预防,治疗和支持性护理对于老龄化PWH人口至关重要.
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