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多基因风险和敌对环境:与青少年时期稳定和动态反社会行为的联系
E L Acland1,2,3, N Pocuca4, S Paquin5
1School of Psychoeducation, University of Montreal, Montreal, QC, Canada.
Development and psychopathology
|February 8, 2024
概括
遗传易感性影响年轻人的反社会行为. 较高的遗传风险和敌对环境与持续的反社会行为有关,在青春晚期,遗传学会缓解环境影响.
科学领域:
- 发展心理学 发展心理学
- 行为遗传学 行为遗传学
- 犯罪学 犯罪学
背景情况:
- 不利的环境与青年反社会行为的增加有关.
- 遗传因素被假设在这种关联中起作用.
- 了解基因与环境的相互作用对于解释反社会性的个体差异至关重要.
研究的目的:
- 调查多基因抗社会风险是否会缓和青少年敌对环境和反社会行为之间的关系.
- 检查青少年时期反社会行为的稳定和动态方面.
- 探索基因环境相互作用在青年反社会发展.
主要方法:
- 从全基因组关联研究中获得了两个反社会性的多基因风险评分 (PRS).
- 在13,15,17岁时评估了反社会行为 (非侵略性行为问题,身体攻击,社会攻击) 和环境敌意 (严厉的家长,学校暴力).
- 利用结构方程模型来分析稳定的 (潜伏的) 和特定时间的 (剩余的) 反社会行为.
主要成果:
- 较高的反社会PRS,苛刻的育儿和学校暴力与整个青春期反社会行为的稳定上升有关.
- 发现了显著的多基因环境相互作用,特别是在青春晚期.
- 在17岁时,严厉的家长与具有较高反社会PRS的个体的社会侵略性增加有关,而具有较低PRS的个体的社会侵略性降低.
结论:
- 遗传学和环境的敌意导致了稳定的青年反社会行为.
- 遗传易感性缓解了家庭环境与反社会行为之间的关联,特别是在青春晚期.
- 研究结果表明,在不同的易感性模型中,遗传倾向会影响对环境逆境的反应.
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