血神经丝轻链蛋白,认知和艾滋病毒感染者的大脑衰老之间的关系
Sarah A Cooley1, Kalen J Petersen1, Caitlin Tice2
1Department of Neurology, Washington University in St. Louis, St. Louis, MO.
AIDS (London, England)
|February 8, 2024
概括
血神经丝轻链蛋白 (NfL) 水平在艾滋病毒感染者 (PWH) 和没有艾滋病毒感染者 (PWoH) 之间没有差异. 在PWH中,较高的NfL与认知障碍和大脑衰老相关,这表明NfL是潜在的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物 生物标志物
- 传染性疾病 传染性疾病
背景情况:
- 神经纤维轻链蛋白 (NfL) 是神经元损伤和神经退行的一个关键指标.
- 血NfL测量为脑脊髓液分析提供了一个不那么侵入性的替代方案.
- 了解艾滋病毒感染者 (PWH) 中的NfL对于评估神经健康至关重要.
研究的目的:
- 为了比较PWH和没有艾滋病毒的人 (PWoH) 的血NfL水平.
- 调查血NfL与认知功能,心血管风险和PWH中的大脑衰老的关联.
- 探索NfL作为PWH中神经退行症的潜在生物标志物.
主要方法:
- 104名PWH和42名PWoH提供了血液样本,并接受了认知测试,心血管风险评估和神经成像.
- 血NfL水平被量化,并在两组之间进行比较.
- 统计分析检查了NfL与年龄,艾滋病毒状况,心血管风险,认知表现和脑年龄差距 (BAG) 之间的关系.
主要成果:
- 血NfL水平在PWH和PWoH之间是可比的.
- 在两组中,高NfL水平与年龄增长相关.
- 在PWH队列中,较高的NfL与更大的心血管风险,认知障碍和更大的大脑年龄差距显著相关.
结论:
- 没有认知障碍的病毒抑制PWH显示了与PWoH相似的NFL水平,这表明有限的持续神经退行.
- 血NfL可以作为一种有价值的生物标志物,用于检测PWH的认知障碍和大脑衰老.
- 需要进一步的纵向研究来阐明NfL在PWH认知衰退中的预测作用.
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