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饮食习惯和巴雷特食道风险之间的因果关系:一个单变量和多变量门德尔随机化研究
Zhen Junhai1, Zeng Suqi2, Deng Beiying2
1Department of General Practice, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, China.
Food & function
|February 8, 2024
概括
这项研究使用了门德尔的随机化来调查饮食和巴雷特食道风险之间的因果关系. 研究结果表明,酒精摄入增加了BE风险,而面包和新鲜水果的消费可能会降低它.
科学领域:
- 胃肠道学和遗传学
- 营养流行病学 营养流行病学
- 因果推理方法 因果推理方法
背景情况:
- 饮食习惯与巴雷特食道风险有关,但因果关系需要严格调查.
- 门德尔随机化 (MR) 提供了一种强大的方法,通过利用遗传变异作为工具变量来评估因果关系.
- 了解这些饮食与BE的联系对于制定有针对性的预防策略至关重要.
研究的目的:
- 系统地检查基因预测的饮食习惯对发展巴雷特食道风险的因果关系.
- 为了确定特定的饮食成分,可能会因果影响BE风险.
主要方法:
- 利用孟德尔的随机化 (MR) 方法与来自英国生物库的遗传变异 (暴露) 和大型GWAS元分析 (结果).
- 分析了17种饮食习惯作为暴露,使用单变量和多变量MR分析.
- 进行了敏感性分析,以确保研究结果的稳定性和有效性,评估潜在的类型.
主要成果:
- 无变MR确定了与饮酒,煮熟的蔬菜,牛肉,面包,新鲜水果,沙拉和干水果与BE风险之间的遗传倾向之间的关联.
- 多变量MR显示,较高的酒精摄入频率与增加的BE风险 (OR=1.74) 之间存在因果关系.
- 提示性证据表明,较高的煮熟蔬菜摄入量增加了BE风险 (OR=2.64),而较高的面包 (OR=0.54) 和新鲜水果 (OR=0.34) 摄入量与BE风险降低有关.
结论:
- 这项MR研究提供了特定饮食习惯与发展巴雷特食道风险之间的因果关系的证据.
- 这些发现突显了饮食修改的潜力,例如减少饮酒和增加水果/面包摄入量,用于预防BE.
- 该研究强调了个性化的饮食建议对于管理BE风险的重要性.
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