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一个智能皮肤的水凝,使可切换的溶液释放

Sai Nikhil Subraveti¹, Sebastian M Peters¹, Morine G Nader¹

¹Department of Chemical & Biomolecular Engineering, University of Maryland, College Park, Maryland 20742, United States.

ACS applied materials & interfaces

|February 8, 2024

概括

研究人员为水凝开发了一种新型的"智能皮肤",可控制,可重复的ON/OFF释放封装溶液. 这一突破为药物输送和其他应用提供了精确的控制.

科学领域:

材料科学材料科学材料科学
聚合物化学聚合物化学
生物医学工程生物医学工程

背景情况:

水凝被广泛用于溶液输送,但快速扩散导致封装物质过早泄漏.
现有的方法缺乏对溶解物释放的精确控制,因此需要一个可调节的开/关传输系统.

研究的目的:

开发一个具有可控制,可重复的开/关开关的水凝系统,用于释放溶液.
为了证明对氧化还原反应的"智能皮肤"在调节溶液扩散方面的有效性.

主要方法:

在水凝周围合成了一种薄而透明的聚合物"智能皮肤",使用氨酸和烯酸单体与乙烯基组.
利用乙烯的氧化还原反应性质,将它们转化为含氧化剂 (例如,H2O2) 的水友硫氧化物,使其释放.
将皮肤恢复到疏水状态,使用减少剂 (例如维生素C) 切换释放OFF.

主要成果:

智能皮肤在OFF状态下表现出快速合成 (∼10分钟) 和有效防止溶液泄漏 (疏水,水接触角度为102°).
氧化刺激成功地将溶解物释放开启 (水友皮肤,水接触角度42°) 和关闭,实现循环控制.
在ON状态下释放速度可以通过调整皮肤厚度和氧化剂度来调整.

结论:

一种新型智能皮肤首次实现了水凝的完美,循环的ON-OFF溶解物释放.
这项技术为药物输送,分离和农业的应用提供了巨大的潜力.
可回氧切换的智能皮肤为控制的溶液输送系统提供了一个多功能平台.

关键词:

智能关门膜是一个智能门.智能门是一个智能门.刺激对刺激有反应的膜.可以切换的膜膜.可调的透性可调.

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