[对于荷尔蒙敏感性小卵性前列腺癌的局部疗法]
Fabian Falkenbach1, Thomas Steuber1,2, Markus Graefen3
1Martini-Klinik Prostatakarzinomzentrum, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland.
Urologie (Heidelberg, Germany)
|February 8, 2024
概括
低基质,荷尔蒙敏感前列腺癌 (omHSPC) 治疗从辅助放射治疗 (RT) 中获益,手术显示了相似的疗效. 现代系统疗法可能会影响omHSPC局部治疗的作用.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 辐射疗法 辐射疗法
背景情况:
- 由于分子成像技术的进步,对荷尔蒙敏感的小细胞瘤前列腺癌 (omHSPC) 的诊断越来越多.
- OmHSPC通常被定义为最多四个骨转移,在常规成像中没有内脏参与.
研究的目的:
- 审查关于omHSPC局部治疗的现有证据,考虑分子成像和当代疗法.
- 突出放射治疗和手术在管理OMHSPC中的作用.
主要方法:
- 一个基于专家共识和指导方针建议的叙事审查.
- 在PubMed (MEDLINE) 进行了非系统的文献搜索.
- 选择了关键研究,以说明omHSPC治疗的发展和基本概念.
主要成果:
- STAMPEDE研究表明,除了抗雄激素剥夺疗法外,前列腺的放射治疗 (RT) 在omHSPC患者中改善了整体存活率 (OS).
- 在3年后,RT显示了OS益处 (81%的RT与73%的没有RT),这在多转移性激素敏感前列腺癌中没有观察到.
- 对omHSPC的外科局部治疗也显示出一个OS优势 (危险比0.44).
结论:
- 建议进行辅助放射治疗 (RT) 来治疗omHSPC.
- 初步证据表明,前列腺切除术的疗效与RT相比.
- 现代系统性组合疗法正在成为对局部治疗在omHSPC管理中的既定作用的挑战.
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