在失眠患者的突出网络内增加功能连接性
Xuejiao Yin1, Tongfei Jiang1, Zhangxiao Song2
1Beijing Key Laboratory of Acupuncture Neuromodulation, Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, China.
Sleep & breathing = Schlaf & Atmung
|February 8, 2024
概括
失眠患者表现出高度突出网络 (SN) 功能连接 (FC),与情绪失调和睡眠质量差相关. 这表明,SN在与伴随性情绪问题相关的失眠背后的机制中至关重要.
科学领域:
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
- 精神病学是一个精神病学.
背景情况:
- 失眠经常与情绪失调同时发生,但潜在的神经机制尚不清楚.
- 突出网络 (SN) 涉及睡眠调节和情绪处理.
- 了解失眠中的SN变化对于解决伴随性情绪症状至关重要.
研究的目的:
- 研究失眠障碍患者的突出网络 (SN) 内的功能连接 (FC) 变化.
- 探索SN FC变化与睡眠质量和情绪困扰的临床测量之间的关系.
主要方法:
- 休息状态功能磁共振成像 (fMRI) 用于30名失眠患者和30名健康对照.
- 进行了基于种子的区域间连接性分析,以检查SN内的FC.
- 心理测量评估包括汉密尔顿抑郁评分表 (HAMD),匹兹堡睡眠质量指数 (PSQI) 和汉密尔顿焦虑评分表 (HAMA).
主要成果:
- 与健康对照组相比,失眠患者在SN内显著增加了FC.
- 改变FC的关键区域包括前带状皮质 (ACC) 和右上额头 (SFG) 之间的连接,以及右岛屿 (INS) 和左上边 (SMG) 之间的连接.
- 增加的SN FC与HAMD,PSQI和HAMA的更高得分有显著的相关性,表明与抑郁症,焦虑症和睡眠不良有关.
结论:
- 突出网络内的高功能连接性与失眠和并发性情绪失调有关.
- 这些发现强调了SN在失眠病理生理学中的关键作用,特别是当伴随着情绪障碍时.
- 准SN可能为经历情绪困难的失眠患者提供新的治疗策略.
更多相关视频
12:09Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
Published on: August 5, 2014
18.1K
08:36Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
Published on: March 21, 2019
7.3K
相关概念视频
Management of Insomnia
248
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
248
Insomnia
85
Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
Multiple factors contribute...
Multiple factors contribute...
85
Insufficient Sleep and Sleep Deprivation
143
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
143
Sleep-Wake Cycles
1.3K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.3K
