酸和 levetiracetam 对症儿童后部段参数的影响
Asena Keles Sahin1, Sevgi Cirakli2
1Department of Ophthalmology, Training and Research Hospital, Ordu University, 52000, Ordu, Turkey. asina_86@hotmail.com.
International ophthalmology
|February 8, 2024
概括
在儿科患者中,酸治疗与视网膜神经纤维层厚度的减少有关. 莱维他似乎对眼睛健康更安全,但建议对这两种药物进行长期监测.
科学领域:
- 眼科和神经病学 眼科和神经病学
- 儿科治疗的管理方法
- 神经眼科并发症 神经眼科并发症
背景情况:
- 影响儿童,需要长期使用抗药物治疗.
- 抗药物的眼部副作用需要彻底调查,特别是在儿科患者群体中.
- 了解氨酸和 levetiracetam 等特定药物对后部段参数的影响,对于患者的安全至关重要.
研究的目的:
- 为了评估后部段参数的变化,特别是视网膜神经纤维层 (RNFL) 和黄斑质细胞层-内状层 (mGCIPL) 厚度的变化.
- 为了比较这些变化在儿童患者用酸单疗法对抗 levetiracetam 至少12个月.
- 评估这些抗药物对儿童眼部结构的安全性.
主要方法:
- 一项涉及45名患有普遍性的儿童 (6-17岁) 和32名健康对照者的研究.
- 患者被分为三个组:甲单疗法, levetiracetam单疗法和健康对照组.
- 用光谱域光学连贯性断层扫描 (OCT) 来测量周周毛囊RNFL和mGCIPL厚度.
主要成果:
- 与 levetiracetam 和对照组相比,接受氨酸单疗法的患者显示RNFL值显著较轻.
- 在 levetiracetam 组和健康对照组之间没有观察到 OCT 参数的显著差异.
- 在甲剂量和平均mGCIPL厚度之间发现了负相关性,这表明剂量依赖的效果.
结论:
- 酸治疗与儿童患者RNFL厚度的减少有关.
- 在这个人群中,Levétiracetam似乎是关于RNFL和mGCIPL厚度的更安全的替代品.
- 建议在长期使用高剂量的甲时谨慎使用,因为可能会引起眼部的副作用.
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