在COVID-19大流行之前和之后,日本青少年的海马体结构
Lin Cai1, Norihide Maikusa1, Yinghan Zhu1
1Center for Evolutionary Cognitive Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.
JAMA network open
|February 8, 2024
概括
这就是COVID-19大流行.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 神经成像是一种神经成像.
背景情况:
- COVID-19 流行病代表着一个重要的全球压力因素.
- 青少年的大脑发育,特别是海马体的可塑性,可能对重大生活事件敏感.
- 有限的研究存在于流行病对青少年大脑结构的影响使用纵向,基于人口的数据.
研究的目的:
- 调查日本首次紧急状态 (SoE) 与青少年海马宏观结构和微观结构的变化之间的联系.
- 评估重大生命事件 (SoE) 对正在发育的海马体的影响.
主要方法:
- 使用了东京TEEN队列研究,一个前性的纵向队列.
- 分析了来自459名青少年 (年龄在11-18岁) 的1060个脑部MRI扫描,这些扫描是在2013-2021年期间收集的.
- 采用了通用添加和线性混合模型来评估SoE和海马体积,子场体积和微观结构措施 (分数异构) 之间的关联.
主要成果:
- 在SoE和增加的平均海马体积之间发现了显著的关联.
- 观察到显著的关联与海马特定子领域 (牙状,CA4,海马-桃体过渡区域) 的体积增加.
- 还发现了与分数异构性增加的显著关联,这表明了微观结构的变化.
结论:
- 在COVID-19大流行期间的第一个紧急状态与青少年海马体体积增加和微观结构变化有关.
- 这些发现表明,主要的生活事件可以影响青少年海马体的结构性可塑性,与典型的发育轨迹相互作用.
- 青少年海马体表现出可塑性,可以通过显著的环境压力因素来调节.
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