COVID-19流行病对酒精使用障碍症状的影响:测试与多基因风险相互作用的测试
Kaitlin E Bountress1, Daniel Bustamante1,2, Mohammad Ahangari1,2
1Virginia Institute for Psychiatry and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.
Journal of American college health : J of ACH
|February 8, 2024
概括
这就是COVID-19大流行.
科学领域:
- 遗传学和行为科学 遗传学和行为科学
- 公共卫生 公共卫生
- 精神病学是一个精神病学.
背景情况:
- COVID-19 流行病带来了独特的挑战,这些挑战可能影响了心理健康和物质使用行为.
- 通过多基因风险评分 (PRS) 测量的遗传倾向可能与环境因素相互作用,以预测酒精使用障碍 (AUD) 症状.
- 了解这些相互作用对于开发有针对性的干预措施至关重要.
研究的目的:
- 研究AUD遗传风险 (PRS) 与COVID-19对大学生AUD症状发展的影响之间的相互作用.
- 为了检查食物/住房不安全和大流行期间物质使用的变化等因素如何与不同祖先群体的AUD症状有关.
主要方法:
- 在COVID-19大流行初期 (2020年3月至5月) 对455名大学生进行的长度研究.
- 利用路径建模来分析AUD PRS,COVID-19影响结构和AUD症状之间的关系.
- 根据祖先群体分层检查的数据:欧洲祖先 (EA),非洲祖先 (AFR) 和美洲祖先 (AMER).
主要成果:
- 在欧洲祖先 (EA) 组中观察到AUD PRS对AUD症状的显著主要影响.
- 粮食和住房不安全预测了美洲祖先 (AMER) 群体的AUD症状.
- 在EA和AMER组中,增加的物质使用与更高的AUD症状有关.
结论:
- 遗传风险,食物/住房不稳定以及增加的物质使用与大学人口中的特定祖先群体中增加的酒精使用障碍症状有关.
- 这些发现强调了在预测AUD症状方面,遗传脆弱性和与流行病相关的环境压力因素之间的复杂相互作用.
- 需要进一步的研究,以探索这些协会在不同的人群和跨越大流行病的不同阶段.
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