Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Cell-type resolved transcriptional network analysis of in vivo cellular senescence following injury.

PLoS computational biology·2026
Same author

Types and frequencies of adverse events across clinical trials for patients with amyotrophic lateral sclerosis: an analysis of the Pooled Resource Open-Access ALS Clinical Trials (PRO-ACT) database.

Amyotrophic lateral sclerosis & frontotemporal degeneration·2026
Same author

Rituximab and IVIG added to plasma exchange improves the outcome of severe CNS demyelinating attacks: a retrospective study.

Therapeutic advances in neurological disorders·2026
Same author

Thalamic nuclei volumes across psychiatric and neurological disorders: a multi-site magnetic resonance imaging study.

Translational psychiatry·2026
Same author

Emergence of multifrequency activity in a laminar neural mass model.

PLoS computational biology·2026
Same author

Mosaic gastruloids reveal a temporal restriction for developmental cell competition.

Nature cell biology·2026
Same journal

Another 10 years of PLOS Computational Biology: A data-driven reflection on trends in genomics research.

PLoS computational biology·2026
Same journal

Mobility data resolution needed to inform predictive models of spatial epidemic spread from mobile phone data.

PLoS computational biology·2026
Same journal

DeepMethylation: A deep learning framework for tissue-specific DNA methylation prediction and functional variant annotation.

PLoS computational biology·2026
Same journal

Redefining and estimating the early-phase reproduction ratio for epidemic outbreaks in spatially structured populations.

PLoS computational biology·2026
Same journal

Optimized phenotype definitions boost GWAS power.

PLoS computational biology·2026
Same journal

Detection, communication, and individual identification with deep audio embeddings: A case study with North Atlantic right whales.

PLoS computational biology·2026
查看所有相关文章

相关实验视频

Updated: Jun 8, 2026

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
09:46

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

Published on: September 21, 2021

4.7K

在多发性硬化症中的多层次网络.

Keith E Kennedy1, Nicole Kerlero de Rosbo2,3, Antonio Uccelli2

  • 1Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain.

PLoS computational biology
|February 8, 2024
PubMed
概括
此摘要是机器生成的。

研究人员使用多组数据绘制了多发性硬化症 (MS) 中复杂的生物途径. 一个关键的发现是MK03蛋白与免疫细胞,视网膜神经纤维层厚度和步行速度的联系,为MS进展提供了洞察力.

更多相关视频

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.5K
Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

9.0K

相关实验视频

Last Updated: Jun 8, 2026

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
09:46

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

Published on: September 21, 2021

4.7K
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.5K
Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

9.0K

科学领域:

  • 神经免疫学 神经免疫学
  • 系统生物学 系统生物学
  • 计算生物学 计算生物学

背景情况:

  • 复杂的疾病,如多发性硬化症 (MS) 涉及复杂的相互作用跨多个生物尺度,从分子到生物体的水平.
  • 了解这些相互关联的尺度对于破译疾病表型和进展至关重要.

研究的目的:

  • 通过使用全面的多学科方法,研究多重硬化症 (MS) 中生物相互作用的多层网络.
  • 确定关键的分子和细胞通路,连接不同的生物尺度,并解释MS的临床表型.

主要方法:

  • 多层网络分析和深度表型化整合了基因组学,蛋白组学,细胞组学,大脑和视网膜成像,以及来自328名多发性硬化症患者和90名对照组的临床数据.
  • 使用相互信息和基于皮尔森相关性的布尔模拟进行拓分析,以确定重要的生物路径.
  • 单细胞水平验证使用流细胞计对特定的已识别的途径.

主要成果:

  • 一个常见的路径将MK03蛋白与总T细胞,视网膜神经纤维层 (RNFL) 厚度和步行速度联系起来.
  • 这一途径涉及与蛋白质酸化,质细胞分化和压力激活的MAPK级联相关的节点.
  • 发现蛋白质 (GSK3AB,HSBP1,RS6) 和免疫细胞 (Th17,CD8,Treg,B记忆) 的特定组合可以解释临床表型.

结论:

  • 识别的布尔模拟路径有效地将分子见解与更高层次的生物尺度相结合,例如视网膜损伤和MS患者残疾.
  • 这些发现为将多发性硬化症的分子基础与其整体临床表现联系起来提供了一个新的框架.
  • 该研究强调了多层网络分析在了解复杂疾病方面的潜力.