透析患者中型肝炎病毒的全球流行病学:系统性审查和元分析
Raoul Kenfack-Momo1, Marceline Djuidje Ngounoue1, Sebastien Kenmoe2
1Department of Biochemistry, The University of Yaounde I, Yaounde, Cameroon.
PloS one
|February 8, 2024
概括
全球范围内,肝炎C病毒 (HCV) 感染在透析患者中很普遍,感染率为24.3%,死亡率为38.7%. 血液透析患者面临特别高的风险,需要采取严格的感染控制措施.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 末期脏病 (ESRD) 的透析患者是易受感染型肝炎病毒 (HCV) 感染高风险的脆弱人群.
- 在接受脏替代疗法的ESRD患者中,HCV感染是致病率和死亡率的重要原因.
- 在透析人群中,全球HCV的流行率和流行病学仍然不完全理解.
研究的目的:
- 估计在接受透析的患者中感染C型肝炎病毒 (HCV) 的全球流行病学.
- 分析基于地理区域,透析类型和诊断方法的HCV流行情况.
主要方法:
- 使用PubMed,Embase,Global Index Medicus和Web of Science进行了全面的文献审查,截至2022年10月.
- 使用包括DerSimonian和Laird模型在内的元分析技术,将HCV患病率估计汇集在一起.
- 进行了异质性,出版偏差和子组分析,以确保 robust 结果.
主要成果:
- 这项研究分析了634篇论文,涉及392,160名参与者.
- 在透析患者中,HCV感染的全球患病率为24.3%.
- 东欧报告了最高的区域患病率 (48.6%),印度尼西亚 (63.6%),血液透析患者的患病率为25.5%. 总体而言,HCV病例死亡率为38.7%.
结论:
- 透析患者,尤其是血液透析患者,表现出大量的HCV感染负担,病例死亡率高.
- 紧急实施严格的感染控制协议在血液透析单位是缓解HCV传播的关键.
- 需要进一步的研究和有针对性的干预措施来解决ESRD透析患者中HCV的全球流行病学问题.
相关概念视频
01:27Dialysis
310
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
310
01:10Retrovirus Life Cycles
46.0K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
46.0K