同时存在的α-托科菲罗尔对奎尔素吸收和代谢的增强作用
Rikito Mitsuzane1, Reiko Okubo1, Miyu Nishikawa2
1Graduate School of Environmental and Life Science, Okayama University, Okayama, Japan.
Free radical research
|February 8, 2024
概括
阿尔法-托科菲罗尔 (αT) 增强氨酸的吸收和新陈代谢,提高血的抗氧化能力. 这种组合影响奎尔丁代谢物,改善抗氧化酶基因表达.
科学领域:
- 营养科学 营养科学
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 奎尔是具有抗氧化特性的黄类.
- 它的生物可用性和有效性可能会受到共同摄入的食品成分的影响.
- 了解这些相互作用对于优化饮食策略至关重要.
研究的目的:
- 为了研究共存的食品成分如何调节奎尔素的吸收和代谢.
- 评估对血抗氧化剂潜力的影响.
- 为了确定对抗氧化酶基因表达的影响.
主要方法:
- 奎尔赛丁单独或与α-托科菲罗尔 (αT),纤维素或蔬菜饮料一起口服给小鼠.
- 血夸塞丁度是在特定时间点测量.
- 分析了抗氧化酶血红氧酶-1的基因表达.
- 在血中鉴定和量化了瑞的代谢物.
- 评估了代谢产物的体外激素清除活性.
主要成果:
- 与quercetin单独相比,αT与quercetin的同时使用显著增加了血Quercetin度.
- 与纤维素结合使用奎尔素降低了血中的奎尔素水平.
- 蔬菜饮料并没有显著改变血Quercetin度.
- 来自用奎尔丁和αT治疗的小鼠的血上调氧酶-1基因表达,与奎尔丁和纤维素不同.
- 检测到八个奎尔丁代谢物,其数量因αT同时服用而改变.
结论:
- 阿尔法-托科菲罗尔 (αT) 增强了奎尔塞丁的吸收和代谢.
- 这种增强增强了血的抗氧化潜力,部分是通过改变氨酸代谢物概况.
- 这些发现表明,αT和氨酸之间有协同效应,改善了抗氧化能力.
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