具有分子确认的银-拉塞尔综合征的成年人身体组成和新陈代谢
Oluwakemi Lokulo-Sodipe1,2, Hazel M Inskip1,3,4, Christopher D Byrne1,4
1Department of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK.
患有银拉塞尔综合征 (SRS) 的成年人表现出不利的身体组成,包括更高的脂肪百分比和更低的瘦肉量. 这种心脏代谢疾病的倾向需要对SRS患者进行主动的健康监测.
科学领域:
- 内分泌学 在内分泌学.
- 人体生理学 人体生理学
- 遗传学 遗传学 是一个
背景情况:
- 出生时体重较低,是Silver-Russell综合征 (SRS) 的特征,与未来的心脏代谢问题有关.
- 有限的数据存在于长期的健康和成人身体组成的个人与SRS.
研究的目的:
- 评估被诊断患有Silver-Russell综合征的成人的身体组成和代谢健康状况.
- 在成人SRS人群中识别潜在的心脏代谢风险.
主要方法:
- 一项观察性研究涉及来自英国研究中心的25名成年人 (≥18岁) 具有分子确认的SRS.
- 评估身体组成 (脂肪量,瘦肉量,骨矿物质密度) 和代谢健康标志物 (血压,脂质,葡萄糖).
- 将SRS个体与来自南安普顿妇女调查 (SWS) 的不受影响的队列进行比较.
主要成果:
- 与SWS队列相比,患有SRS的成年人表现出明显更高的脂肪百分比 (44.1%vs30.3%) 和较低的瘦肉百分比 (51.8%vs66.2%).
- 在SRS组中观察到较低的骨矿物质密度 (BMD) (1.08对1.24).
- 患有心脏代谢风险因子的比例较高:52%的总胆固醇高,20.8%的高甘油三,25%的高禁食葡萄糖,以及33.3%的高血压.
结论:
- 患有银-拉塞尔综合征的成年人具有不良的身体组成概况.
- 在患有SRS的成年人中,有明显的心脏代谢疾病的倾向.
- 这些发现强调了实施SRS患者健康监测策略的重要性,以防止不良健康结果.
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