1型糖尿病患者的食后运动周围的血糖管理:挑战被接受
Simon Helleputte1,2, Jan Stautemas1, Laura Jansseune1
1Faculty of Medicine and Health Sciences, Ghent University, Ghent 9000, Belgium.
The Journal of clinical endocrinology and metabolism
|February 8, 2024
概括
在1型糖尿病 (T1D) 中,食后运动有效降低活动期间和之后的血糖 (BG). 然而,需要谨慎管理,以解决潜在的运动后高血糖和夜间低血糖.
科学领域:
- 内分泌学 在内分泌学.
- 运动生理学 运动生理学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 餐后运动对1型糖尿病 (T1D) 的血糖控制的影响需要进一步澄清.
- 了解这些影响对于有效管理血糖 (BG) 水平至关重要.
研究的目的:
- 研究1型糖尿病的成年人中食后运动的急性,亚急性和晚期血糖影响.
- 为了比较不同的运动强度 (步行,中度,高强度间隔) 与静止控制.
主要方法:
- 一个随机对照试验,涉及8名T1D成年人.
- 四次实验室访问包括30分钟的休息 (控制),步行 (步行),中度 (MOD) 或间歇性高强度 (IHE) 运动,饭后60分钟.
- 24小时的随访监测血糖 (BG) 变化.
主要成果:
- 与对照组相比,所有运动方式都显著降低了食后葡萄糖 (PPG) 排泄量,并观察到显著的BG下降.
- 运动期间没有出现低血糖症;然而,观察到运动后高血糖症和增加的夜间低血糖症.
- 中等强度和间歇性高强度运动比步行显示出更大的BG减少,但差异并不总是统计学上显著的.
结论:
- 当采取适当的预防措施,如减少胰岛素时,食后运动是有效和安全的,可以降低T1D中的PPG外流.
- 主要挑战仍然存在:管理运动后亚急性高血糖症和预防夜间低血糖症.
- 需要进一步的研究来优化T1D管理的运动时间和强度.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.4K
Insulin: Dosing Regimen and Adverse Effects
173
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
173
Diabetes: Management and Pharmacotherapy
285
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
285
Hypoglycemia and Glucagon
263
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
263
Glucose Homeostasis: Regulation of Blood Glucose
1.6K
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
1.6K
Diabetes Mellitus: Overview and Type I Subtype
2.6K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.6K


