在膀癌中使用药物载荷的Bacillus Calmette-Guérin细菌进行免疫化疗组合治疗

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Kangkang Liu¹, Lining Wang¹, Jing Peng²

¹Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.

Advanced materials (Deerfield Beach, Fla.)

|February 8, 2024

概括

在膀癌的治疗中,静脉内巴塞卢斯卡尔梅特-盖林 (BCG) 疗法显示出有限的成功. 一种新的方法使用载有多克索鲁比的BCG纳米颗粒 (DOX@BCG) 来提高治疗效率并减少副作用.

科学领域:

在瘤学瘤学.
生物技术是生物技术.
纳米医学是一种纳米医学.

背景情况:

肠道Bacillus Calmette-Guérin (BCG) 是高风险的非肌肉侵入性膀癌 (NMIBC) 的标准.
超过50%的NMIBC患者经历了复发或进展,尽管BCG治疗.
目前与化疗联合治疗的有效性有限,副作用严重.

研究的目的:

开发一种用于增强膀癌治疗的新型药物输送系统.
为了提高内BCG治疗NMIBC的疗效和安全性.

主要方法:

采用"生物素-斯特雷普塔维丁策略"将多克索鲁比辛 (DOX) 封装成活BCG细菌 (DOX@BCG) 中的纳米颗粒.
评估了DOX@BCG的向性,有效性和安全性,用于骨质型膀癌的临床前模型.

主要成果:

DOX@BCG通过BCG粘附到上皮表皮表现出精确的向膀瘤细胞.
在临床前模型中,组合疗法协同抑制了癌症进展和延长了生存时间.
DOX@BCG表现出改善的耐受性,生物安全性和诱导的抗瘤免疫力.

结论:

DOX@BCG代表了一种有前途的药物输送系统,用于静脉膀癌治疗.
这种方法利用BCG免疫疗法,DOX化疗和免疫细胞死亡来改善治疗结果.
DOX@BCG系统在管理NMIBC方面具有显著的临床转化潜力.

关键词:

在BCG中,BCG是BCG.细菌传递系统的细菌传递系统.膀癌:膀癌是一种癌症.化学疗法化疗化疗免疫疗法免疫疗法

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