感觉性慢性炎症性脱叶林性多基隆性神经病变:被忽视的免疫疗法响应感觉神经病变
1Department of Neurology, University of Alabama at Birmingham, Veterans Affairs Medical Center, Birmingham, AL, USA. shinj.oh@icloud.com.
Journal of clinical neurology (Seoul, Korea)
|February 8, 2024
概括
感觉性慢性炎症性脱髓化多基原蛋白神经病变 (CIDP) 是一种可治疗的疾病. 大多数有感官CIDP的患者在免疫治疗中得到改善,显示出这种情况.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
背景情况:
- 感觉性慢性炎症性脱髓化多基核神经病 (CIDP) 是一种罕见的神经疾病.
- 诊断和治疗感官CIDP可能是具有挑战性的.
研究的目的:
- 评估免疫治疗在被诊断患有感觉性CIDP的患者中的有效性.
- 突出感官CIDP作为CIDP的一个独特和可治疗的变体.
主要方法:
- 根据特定的诊断标准确定了56名有感觉性CIDP的患者.
- 用电生理学研究 (神经导电研究) 和神经活检来确认脱髓化.
- 评估了免疫治疗后患者的结果.
主要成果:
- 免疫疗法适用于79%的随访患者.
- 在接受免疫治疗的88%患者中观察到显著改善.
- 常规的运动神经传导研究在70%的病例中证实了脱髓化.
结论:
- 感官CIDP显示了免疫治疗的高响应率 (88%).
- 常规的运动神经传导研究在诊断感官CIDP时是有效的.
- 感官CIDP应该被认为是一种可治疗的异常感官神经病变形式.
更多相关视频
09:38Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
Published on: September 12, 2016
12.3K
07:30A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
Published on: November 9, 2017
9.3K
相关概念视频
T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
Tumor Immunotherapy
524
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
524
