轻度认知障碍和痴呆症中的代谢和环境生物标志物:一项探索性研究
Abigail C Lyon1, Carol F Lippa1, Arnold R Eiser2
1Department of Neurology, Cognitive Disorders & Comprehensive Alzheimer's Disease Center, Vickie & Jack Farber Institute for Neuroscience, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Journal of integrative and complementary medicine
|February 8, 2024
概括
常见的血液检查显示,在患有轻度认知障碍 (MCI) 和痴呆症 (DE) 的患者中,有许多金属和代谢异常. 超过90%的人至少有一种生物标志物,这表明多种因素导致认知能力下降.
科学领域:
- 神经学 神经学
- 毒理学 毒理学 毒理学
- 生物化学 生物化学
背景情况:
- 阿尔茨海默病 (AD) 和其他认知障碍是多因素的.
- 通过可访问的诊断来识别促成因素对于早期干预至关重要.
- 血液测试提供了一种非侵入性的方法来评估潜在的致病因素.
研究的目的:
- 确定患有轻度认知障碍 (MCI) 和痴呆症 (DE) 的患者中病原性因素,包括金属和代谢物的患病率.
- 评估常见的血液检测在识别这些因素中的有用性.
- 探索已识别的生物标志物与疾病阶段之间的关系.
主要方法:
- 分析了符合MCI和轻度至中度痴呆症 (DE) 标准的患者的血清样本.
- 测试包括金属 (,,,铁,铜),氨,同类,维生素B12,叶酸,甲状腺功能,代谢产品和炎症标志物.
- 审查了药物使用,特别是质子抑制剂.
主要成果:
- 在超过一半的受试者中发现了金属异常 (有毒和基本) (64%的DE,66%的MCI).
- 同型囊血是最常见的异常 (71% DE,67% MCI).
- 近一半的人表现出胰岛素耐药性 (44%DE,52%MCI),92%的人至少有一种异常生物标志物.
结论:
- 有毒金属,过度的必需金属 (铜,铁),以及代谢/肝因子在MCI和DE中均可检测到.
- 许多因素可能会导致痴呆症的进展.
- 针对这些生物标志物的个性化干预措施可能有助于减少认知衰退.
相关概念视频
Alzheimer's Disease: Overview
484
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
484
Dementia
113
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
113
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
125
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
125
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
92
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
92


