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在Brachionus plicatilis中由hexabromocyclododecane诱导的生殖毒性:影响和评估

Na Lu¹, Yaya Zhang¹, Qinglin Mu²

¹Department of Marine Ecology, College of Marine Life Sciences, Ocean University of China, No.5 Yushan Road, Qingdao, China; Laboratory for Marine Ecology and Environmental Science, Qingdao Marine Science and Technology Center, No.1 Wenhai Road, Qingdao, China.

Aquatic toxicology (Amsterdam, Netherlands)

|February 8, 2024

概括

赫克萨布罗摩环多达干 (HBCD) 严重影响海洋浮游生物的繁殖和生存. 这项研究揭示了HBCD.

科学领域:

环境毒理学环境毒理学
海洋生物学海洋生物学
生态毒理学生态毒理学

背景情况:

赫克萨布罗摩环丁 (HBCD) 是一种广泛使用的阻燃剂,具有潜在的海洋生态系统影响.
有限的数据存在于低性海洋生物的HBCD毒性.

研究的目的:

在海洋动物浮游生物模型,Brachionus plicatilis.中研究HBCD的生殖毒性.
阐明HBCD诱导毒性的潜在机制,包括氧化应激和亡.

主要方法:

在Brachionus plicatilis被不同度的HBCD所暴露的次致命性.
评估生殖终点 (后代数量,人口增长率).
测量氧化应激标志物 (ROS,MDA) 和亡指标 (Caspase-3,9).

主要成果:

根据度,HBCD显著降低了后代产量和人口增长率 (r_m,R_0).
生殖时间和个体生长 (体长) 受到HBCD暴露的负面影响.
增加的活性氧物种 (ROS) 和甲 (MDA) 表示氧化应激,与亡有关.

结论:

在Brachionus plicatilis中,HBCD表现出显著的生殖毒性,主要是通过氧化应激和亡.
该研究确定了HBCD的有毒度范围,这对于海洋生态系统的环境风险评估至关重要.

关键词:

细胞灭亡 (apoptosis) 是一种死亡的过程.这就是HBCD的原因.海洋面包机的面包机氧化应激是一种氧化应激.有反应性氧物种的反应性氧物种.风险评估风险评估风险评估

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