阻塞性睡眠呼吸暂停的内型在老年创伤暴露的退伍军人中是相似的,有和没有被诊断为PTSD
Elliot J Brooker1, Shane A Landry2, Dwayne Mann3
1School of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University, Clayton, Victoria, 3800, Australia.
Sleep medicine
|February 8, 2024
概括
阻塞性睡眠呼吸暂停 (OSA) 在患有创伤后应激障碍 (PTSD) 的退伍军人中很常见. 这项研究没有发现PTSD和没有PTSD的退伍军人之间OSA内型的显著差异,这表明PTSD不会直接改变这些睡眠呼吸暂停机制.
科学领域:
- 睡眠医学 睡眠医学
- 精神病学是一个精神病学.
- 退伍军人健康 退伍军人的健康
背景情况:
- 大约60%的患有创伤后应激障碍 (PTSD) 的退伍军人也患有阻塞性睡眠呼吸暂停 (OSA).
- 在患有PTSD的个体中OSA的高患病率的根本原因尚未完全理解.
- 创伤后应激障碍可能会影响导致OSA发展的特定内型.
研究的目的:
- 为了调查关键阻塞性睡眠呼吸暂停 (OSA) 基因型是否在与PTSD和OSA并发症的退伍军人与仅患有OSA的退伍军人之间有所不同.
- 探索PTSD对OSA患者上呼吸道缩性,肌肉补偿,循环增益和兴奋值的潜在影响.
主要方法:
- 一项回顾性队列研究分析了21名患有PTSD和OSA的退伍军人和27名仅患有OSA的退伍军人的多眠学数据.
- 参与者是年长的澳大利亚男性越南战争退伍军人,患有轻度至重度的OSA.
- 测量了阻塞性睡眠呼吸暂停的内型,包括上呼吸道折叠性,肌肉补偿,循环增益和唤醒值.
主要成果:
- 在PTSD + OSA组和仅使用OSA组之间,在上呼吸道折叠性,肌肉补偿,循环增益或唤醒值方面没有发现显著差异.
- 关键的OSA内型特征在两组退伍军人中都是相似的.
- 在这两组研究中,年龄和BMI是可比的.
结论:
- 患有PTSD的退伍军人的阻塞性睡眠呼吸暂停内型与仅患有OSA的创伤暴露退伍军人的内型相似.
- 创伤后应激障碍似乎对OSA内型具有最小的直接影响,超出了年龄和创伤暴露的潜在影响.
- 在PTSD中增加的OSA患病率背后的病因尚不清楚,因此需要对更大,更多样化的样本进行进一步调查.
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