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一个基于物联网的食感器生物芯片用于诊断牙周病

Thi Thanh-Qui Nguyen¹, Eun-Mi Lee², Thi Thanh-Thao Dang¹

¹Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Anam-dong, Seongbuk-gu, Seoul, 02841, Republic of Korea.

Biosensors & bioelectronics

|February 8, 2024

概括

一个新的便携式诊断系统使用微流体芯片和智能手机应用程序快速,准确地检测牙周炎生物标志物ODAM,帮助早期诊断.

科学领域:

生物医学工程生物医学工程
临床诊断临床诊断临床诊断临床诊断
生物传感器技术技术

背景情况:

严重的牙周炎影响全球近10亿人,需要改进早期诊断方法.
目前的牙周炎诊断方法可能耗时,需要专门的实验室设置.
识别特定的生物标志物,如牙产生的骨髓细胞相关蛋白 (ODAM),对于及时干预至关重要.

研究的目的:

开发一个集成的,自动化的系统,以快速,准确地检测牙周炎生物标志物ODAM.
创建一个用户友好的诊断工具,利用微流体,3D打印和智能手机连接.
建立一种新的生物传感器,用于对牙周炎风险进行非侵入性现场评估.

主要方法:

使用3D打印制造聚甲基甲酸 (PMMA) 微流体芯片的制造.
开发一种三明治型光吸收传感器,使用特定的吸收体对来进行ODAM检测.
将微流体芯片集成到基于物联网 (IoT) 的自动便携式诊断设备中,由智能手机应用程序控制.
使用CMOS摄像头和LED激发用于光信号测量和基于智能手机的数据可视化.

主要成果:

集成系统在30分钟内实现了ODAM快速检测.
在缓冲条件下,确定了0.011nM的高度敏感的检测极限 (LOD).
临床评估表明100%的特异性在区分低风险和高风险个人牙周炎.

结论:

开发的基于光的微流体吸口传感器与基于物联网的POC系统集成,为牙周炎诊断提供了一个有前途的解决方案.
该系统可以在现场进行非侵入性,快速和准确的ODAM检测.
这项技术具有很强的临床转化潜力,可促进牙周炎的早期和有效治疗.

关键词:

微流体吸食传感器是一种微流体吸食传感器奥达姆 (Odam) 是一个叫做奥达姆的人.牙周病的诊断牙周病的诊断护理点 (POC) 设备的使用.这是一种三明治类型的绑定.

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