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相关概念视频

Infertility in Males01:23

Infertility in Males

264
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
264
Infertility in Females01:28

Infertility in Females

298
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
298
In Vitro Fertilization01:24

In Vitro Fertilization

265
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
265
Oogenesis02:07

Oogenesis

63.7K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.7K
Fertilization01:38

Fertilization

71.0K
During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
71.0K
Spermatogenesis01:41

Spermatogenesis

102.5K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.5K

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Updated: Jul 4, 2025

Exploring X Chromosomal Aberrations in Ovarian Cells by Using Fluorescence In Situ Hybridization
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用IDDB Xtra解读包括不孕症在内的综合知识库景观.

Qian Li1, Zhijie Hu2, Jiayin He1

  • 1Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai, 200011, China; Medicinal Bioinformatics Center, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai, 200025, China.

Computers in biology and medicine
|February 8, 2024
PubMed
概括

不孕症影响全球15%的夫妇,通常是由于遗传原因. IDDB Xtra是一个新的数据库,整合了遗传,表观遗传和表型数据,以帮助不孕症诊断和治疗研究.

关键词:
染色体异常 染色体异常表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.基因组学就是基因组学.不孕症 不孕不育 不孕不育 不孕不育导致不孕症的基因是不孕症.知识图表知识图表调节器是指调节器.突变 突变 突变 突变现象类型 现象类型研究应用研究应用.

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科学领域:

  • 遗传学 是一个遗传学.
  • 生殖生物学 生殖生物学
  • 生物信息学是一种生物信息学.

背景情况:

  • 不孕症影响全球约15%的夫妇,遗传因素导致一半的病例.
  • 现有的资源缺乏对不孕症相关数据的全面描述,这阻碍了深入的研究和遗传咨询.
  • 高通量测序的进步需要综合的基因诊断平台和潜在的治疗策略.

研究的目的:

  • 开发IDDB Xtra,一个增强的数据库,集成用于不孕症研究和遗传咨询的各种数据类型.
  • 为研究人员和临床医生提供交互式工具,以探索不育机制,并促进遗传咨询.

主要方法:

  • 将表型表现,基因组数据集,表观遗传学和调节器集成到现有的不孕症数据库 (IDDB).
  • 2369个基因,273个染色体异常,884个表型,60个基因组数据集,464个表观遗传记录和1144个调节器的手动策划.
  • 整合定制的图形应用程序来分析发育地图,突变效应和临床表现.

主要成果:

  • IDDB Xtra 拥有与不孕症诊断和治疗相关的综合数据库.
  • 交互式工具使用户能够在不同发育阶段探索基因功能,过候选基因并识别潜在的变异.
  • 该平台促进了与不孕症相关的生物医学网络的检索,有助于了解疾病机制.

结论:

  • IDDB Xtra 作为捕获和组织不孕症研究数据的宝贵资源.
  • 集成的平台和交互式工具促进了遗传咨询,并加速了治疗不孕症的药物发现.
  • IDDB Xtra是免费在线访问的,促进合作研究和生殖健康的临床应用.