使用大麻素作为德克萨米他辅助治疗的潜力:用狗外周血液单核细胞进行体外研究
Sabrina Dixon1, Arpita Deb1, Todd Archer2
1Center for Environmental Health Sciences, Department of Comparative Biomedical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, USA.
Veterinary immunology and immunopathology
|February 8, 2024
概括
像CBD和THC这样的大麻素可能会增强德克萨米他的作用.
科学领域:
- 兽医药理学 兽医药理学
- 免疫学 免疫学 免疫学
- 大麻素科学 大麻素科学
背景情况:
- 德克萨米他 (dex) 是一种强效的葡萄糖皮质类药物,在兽医中广泛用于治疗各种疾病.
- 系统性德克萨米他的使用可能会导致显著的副作用,影响治疗的遵守性和疗效.
- 寻求辅助疗法来降低德克萨米他剂量并减轻副作用,同时保持免疫抑制作用.
研究的目的:
- 调查大麻素的潜力,特别是大麻二醇 (CBD) 和 Δ9-四大麻 (THC),作为德克萨治疗的辅助剂.
- 评估CBD和/或THC与甲结合时对狗外周血液单核细胞 (PBMCs) 免疫功能的影响.
主要方法:
- 狗外周血液单核细胞 (PBMC) 用不同度的德克萨米他治疗.
- 评估了德克萨米他的作用,并没有添加大麻素 (CBD) 和/或 Δ9-四大麻素 (THC).
- 通过测量IFN-γ蛋白分泌和INFG和TNFAmRNA表达来评估免疫功能.
主要成果:
- 德克萨米他以度依赖的方式抑制了IFN-γ蛋白质的分泌.
- 低剂量德克萨米他的免疫抑制作用被CBD,THC或它们的组合所增强.
- 在INFG和TNFA mRNA表达上观察到类似的协同效应.
结论:
- 大麻素 (CBD) 和 Δ9-四大麻素 (THC) 显示出在兽医中作为甲辅助疗法的潜力.
- 将大麻素与德克萨米他结合起来,可能可以减少德克萨米他的剂量,从而最大限度地减少副作用.
- 这些发现支持对CBD和THC进行进一步的体内研究,以控制动物的炎症和免疫介导疾病.
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