在患有分泌管疾病的患者中,结肠镜后结肠直肠癌的风险:基于人口的队列研究
Frederikke S Troelsen1,2, Henrik T Sørensen1, Rune Erichsen1,2
1Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
患有分歧性疾病的患者可能会略有增加近位结肠镜后结肠直肠癌 (PCCRCs) 的风险. 这项研究调查了经过结肠镜检查的患有或没有分泌管疾病的患者的PCCRC风险.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 结肠镜后结肠直肠癌 (PCCRCs) 在患有分泌管疾病的患者中占结肠直肠癌 (CRCs) 的很大一部分.
- 这种人群中PCCRC的确切风险在很大程度上仍未得到量化.
研究的目的:
- 为了确定与没有分歧性疾病的患者相比,在患有分歧性疾病的患者中PCCRC的绝对和相对风险.
- 根据癌症位置 (近端与远端) 分析PCCRC风险.
主要方法:
- 从1995年到2015年进行了一项队列研究,其中包括接受了结肠镜检查的患有和没有分泌管疾病的患者.
- 累积发病率比例 (CIP) 和Cox比例危险回归模型用于计算PCCRC风险和危险比率 (HR).
- 分析根据PCCRC位置进行了分层,并计算了3年PCCRC率.
主要成果:
- 7-36个月的PCCRC累积发病率比例在患有分支管疾病的患者中为0.45%,在没有分支管疾病的患者中为0.36%.
- 对任何PCCRC的调整HR为0.84 (95%CI为0.73-0.97) 对于患有分歧性疾病的患者.
- 在患有分歧性疾病的患者中,观察到近端PCCRC的相对风险较高 (HR 1.23,95%CI 1.01-1.50).
结论:
- 虽然PCCRC的总体绝对风险较低,但患有分歧性疾病的患者在结肠镜检查后可能面临近位PCCRC的相对风险较高.
- 这些发现凸显了在CRC查和监测策略中考虑分歧性疾病状态的重要性.
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