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马森松花粉 (Pinus massoniana) 激活HD11的巨引发了这种情况

Daniel Brugger¹, Belinda Wilhelm², Benjamin Schusser³

¹Institute of Animal Nutrition and Dietetics, Vetsuisse-Faculty, University of Zurich, Winterthurerstrasse 270, 8057, Zurich, Switzerland; Chair of Animal Nutrition, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Liesel-Beckmann-Strasse 2, 85354, Freising, Germany.

Journal of ethnopharmacology

|February 8, 2024

概括

马森松花粉在体外激活巨细胞,可能是由于细菌脂多糖 (LPS) 和其他花粉成分. 需要进一步的研究来确定这些特定的免疫刺激化合物.

科学领域:

免疫学免疫学免疫学
药理学药理学是指药理学的学科.
传统中国医药传统中国医药

背景情况:

马森松花粉 (Pinus massoniana; MP) 在中国传统医学 (TCM) 中用于治疗肠道疾病.
在体内研究表明,MP与胃肠道免疫系统相互作用.

研究的目的:

为了研究MP的体外激活HD11巨细胞.
分析生产地点和收获年对MP免疫调节效应的影响.

主要方法:

来自不同来源和年份的MP批量被分析为内毒活性 (LAL测试),脂肪酸 (GC-MS) 和微生物污染.
用MP或脂聚糖 (LPS) 刺激HD11巨细胞,以测量氧化 (NO) 生产和免疫基因表达 (RT-qPCR).

主要成果:

MP激活了HD11巨细胞,由增加的NO释放和改变的免疫基因表达体现.
在MP中,含有显著水平的3 - 二多德卡诺酸和3 - 米里斯酸.
虽然细菌LPS有助于该效应,但大约80%的MP活性是独立于LPS的,正如polymyxin-B (PMB) 抑制所示.

结论:

马森松花粉在体外激活的巨细胞.
细菌LPS是部分激活剂,但其他花粉衍生的成分,可能是多糖和寡糖,是主要的贡献者.
对于MP的免疫调节潜力,需要对特定活性成分进行进一步的研究.

关键词:

肠道健康肠道健康免疫系统的免疫系统.脂聚糖类糖化物脂聚糖类糖化物传统的中国医学是传统的中国医学.

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