与COVID-19持续后果患者的认知障碍相关的因素
Aaron Bonner-Jackson1, Rohun Vangal2, Yadi Li3
1Neurological Institute, Section of Neuropsychology; Lou Ruvo Center for Brain Health, Cleveland Clinic, Ohio.
The American journal of medicine
|February 8, 2024
概括
患有COVID-19 (PASC) 后急性后续症状的患者表现出显著的认知缺陷,近44%的患者在感染后7个月左右出现损伤. 较高的体重指数与PASC患者的认知功能障碍有关.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 认知科学 认知科学
背景情况:
- COVID-19 (PASC) 后急性后果可能表现为神经和认知症状.
- 了解PASC认知障碍的患病率和预测因素对于患者管理至关重要.
研究的目的:
- 为了量化PASC患者的认知缺陷.
- 在PASC人群中确定与认知障碍相关的关键变量.
主要方法:
- 对确诊COVID-19的患者进行了全面的神经心理评估.
- 认知障碍被定义为6个认知领域中的至少一个的复合T分数≤35.
- 多变量后勤回归分析了包括人口统计,COVID-19严重程度,临床因素和情绪在内的预测因素.
主要成果:
- 与对照组相比,患有PASC的患者显著更有可能表现出认知障碍 (OR 3.61).
- 在记忆,语言,处理速度,视觉空间和执行功能领域观察到障碍.
- 更高的体重指数是PASC患者与没有认知障碍之间的唯一显著差异.
结论:
- 与健康人相比,PASC患者的认知功能障碍的可能性增加了近四倍.
- 大约44%的PASC患者在感染后7个月左右出现认知缺陷.
- 虽然预估的患病前智力与损伤相关,但高BMI独特地区分了受损的PASC患者.
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