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医疗保健资源利用和与异构血造干细胞移植相关的成本:一个范围审查
Nancy V Kim1, Gemma McErlean2, Serena Yu1
1Centre for Health Economics Research and Evaluation, University of Technology Sydney.
Transplantation and cellular therapy
|February 8, 2024
概括
本综述强调了全源造血干细胞移植 (allo-HSCT) 的显著医疗资源利用和成本. 了解这些需求对于确保患者获得这种救命手术至关重要.
科学领域:
- 血液学 血液学 血液学
- 卫生经济学 卫生经济学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 全基性造血干细胞移植 (allo-HSCT) 是一个复杂的程序,具有相当大的资源影响.
- 关于医疗保健资源利用 (HRU) 和与allo-HSCT相关的成本的现有文献是分散的.
- 需要一个全面的摘要,以告知利益相关者关于all-HSCT的经济和资源需求.
研究的目的:
- 进行范围审查,总结有关医疗保健资源利用率 (HRU) 和与成人allo-HSCT相关的成本的证据.
- 从相关研究中识别和综合报告的HRU措施和成本数据.
- 突出报告中的异质性,并确定文献中的差距.
主要方法:
- 采用了基于Joanne Briggs研究所指导方针的系统范围审查方法.
- 在PubMed,Embase和Health Business Elite电子数据库以及灰色文献中进行了搜索,截至2022年11月.
- 包括报告HRU和/或成人allo-HSCT成本的研究,数据提取和合成由两个独立审查员进行.
主要成果:
- 确定了43项关于HRU,成本或两者的研究,用于all-HSCT.
- 大多数研究报告了成本 (93.0%) 和HRU (81.4%),许多研究报告了两者 (74.4%).
- 住院时间是最常见的HRU指标. 总的Allo-HSCT成本差异很大,从63,096美元到782,190美元在100天内和69,218美元到637,193美元在1年内.
结论:
- 在HRU和成本的报告中存在显著的异质性,这使得最终的结论变得复杂.
- 对短期和长期资源需求的认识对于临床医生,政策制定者和政府来说至关重要,以确保获得护理.
- 需要进一步的研究来确定HRU和成本的关键决定因素,以优化HSCT服务的设计和交付.
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