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几种三烯衍生物对登革病毒的潜在作用

Seynabou Sokhna1, Natacha Mérindol2, Marc Presset3

  • 1Laboratoire de Chimie Organique et Thérapeutique, Faculté de Médecine, de Pharmacie et d'Odontologie de l'Université Cheikh Anta Diop de Dakar, BP 5005 Dakar-Fann, Sénégal; UMR 7182, ICMPE, Institut de Chimie et des Matériaux Paris Est, Thiais, France; Equipe de recherche chimie organique et thérapeutique (ECOT) de l'Université Alioune Diop de Bambey. BP 30 Région de Diourbel, Sénégal.

Bioorganic & medicinal chemistry letters
|February 8, 2024
PubMed
概括

新的三烯化合物在实验室研究中显示出对登革热病毒 (DENV) 的强烈抗病毒活性. 这些有前途的分子为开发新型登革热治疗提供了潜在的起点.

关键词:
这是一种抗登革热的药物.细胞毒性 细胞毒性这就是DENV的意义.发烧 发烧 发烧三亚烯是一种三亚烯.

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The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the...
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