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Miguel Paz-Alvarez1, Chun Fung Tang1, Paul D Pudney2
1UCL School of Pharmacy, 29-39 Brunswick Square WC1N 1AX, London, UK.
International journal of pharmaceutics
|February 8, 2024
概括
这项研究研究了用于治疗头皮的气象 (CBZ) 输送. 相比于简单的溶剂,复杂的配方增强了CBZ的皮肤透,根据载体成分产生不同的效果.
科学领域:
- 皮肤病学和制药科学 皮肤病学和制药科学
- 化品科学 化品科学
- 药物输送系统 药物输送系统
背景情况:
- 头皮 (pityriasis capitis simplex) 涉及头皮脱落,脱落和障碍功能受损.
- 气候 (CBZ) 是一种用于管理的抗真菌剂.
- 以前的研究描述了CBZ及其从整洁溶剂的皮肤透.
研究的目的:
- 为了评估复杂配方CBZ的体外人体皮肤透率.
- 评估各种溶剂系统对CBZ皮肤吸收和透的影响.
- 为了确定配方中的单个溶剂的皮肤保留和透.
主要方法:
- 使用人体皮肤进行体外透研究.
- 配方包括烯基醇 (PG),Transcutol®P (TC),乙烯酸盐 (OSal) 和异醇 (IPA).
- 开发和验证用于皮肤中的PG,TC和OSal量化新分析方法.
主要成果:
- 所有测试的车辆都促进了CBZ皮肤透.
- 二进制 (PG:TC,TC:OSal) 和三进制 (PG:IPA:OSal) 车辆在CBZ透方面没有显著差异.
- 与纯溶剂相比,二元载体通常会增强CBZ的皮肤吸收;PG含量会影响PG:TC和PG:IPA:OS系统中的CBZ透.
- 在二进制系统中,TC比PG更容易透皮肤.
- 盐含量没有显著影响CBZ吸收或透.
结论:
- 复杂的配方增强了气象 (CBZ) 的皮肤透力,用于治疗头皮.
- 配方成分显著影响CBZ皮肤传递,并且不能普遍预测效果.
- 了解溶剂效应对于优化局部抗真菌配方至关重要.
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