生衍生的生物活性化合物减弱了人类树突细胞的托尔类受体介导反应
Kitti Pázmándi1, Beatrix Ágics2, Attila Gábor Szöllősi1
1Department of Immunology, Faculty of Medicine, University of Debrecen, 1 Egyetem Square, H-4032, Debrecen, Hungary.
European journal of pharmacology
|February 8, 2024
概括
生化合物6-gingerol和6-shogaol可以抑制免疫细胞的功能. 这些植物化学物质减少树突细胞激活和T细胞反应,为炎症疾病治疗提供了潜在的可能性.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
- 自然产品化学 自然产品化学
背景情况:
- 生具有长期的药用历史,人们越来越关注其对自身免疫和炎症性疾病的抗炎性质.
- 生植物化学物质影响人类免疫细胞,特别是树突细胞 (DCs) 的精确机制在很大程度上是未知的.
研究的目的:
- 调查关键的生化合物6-gingerol和6-shogaol对初级人类单细胞衍生树突细胞 (moDCs) 的功能的影响.
- 阐明参与这些生化合物的免疫调节作用的信号通路.
主要方法:
- 用不同度的6 - 生醇和6 - 醇治疗人类的moDCs.
- 评估DC激活标记物,细胞因子生产和T细胞刺激能力.
- 关键信号通路的分析,包括核因子-κB (NF-κB),基因激活蛋白激酶 (MAPK),哺乳动物目标拉巴素 (mTOR),AMP激活蛋白激酶 (AMPK) 和核因子红色素2相关因子2 (NRF2).
主要成果:
- 6 - 银醇和6 - Shogaol都显著抑制了moDC激活,细胞因子的产生和T细胞刺激能力,以剂量依赖的方式.
- 这些生化合物通过抑制NF-κB,MAPK和mTOR信号通路来抑制DC功能.
- 6-shogaol,但不是6-gingerol,激活了AMPK和NRF2通路,这表明它可能具有更强大的抗炎作用.
结论:
- 由生衍生的6-醇和6-醇具有强大的免疫调节作用,主要是通过抑制人类树突细胞活动.
- 抗炎作用通过多个信号通路进行介导,而6-shogaol表现出更大的效力.
- 这些发现突出了生化合物的治疗潜力,用于控制炎症和自身免疫性疾病.
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