莱涅佐利德诱导的乳酸性酸症
Venkat Ramesh1, Santosh Gattu2, Maryam Maqsood3
1Infectious Diseases, Apollo Hospitals, Hyderabad, India venkatramesh.ramesh@gmail.com.
BMJ case reports
|February 8, 2024
概括
利尼佐利德抗生素很少会导致乳酸,这是一个严重的疾病. 在患有多药耐药结核病的患者中,停止使用linezolid可以解决乳酸化症,这表明存在因果关系.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 关键护理医学 关键护理医学
背景情况:
- 利尼佐利德是治疗多抗药性格拉姆阳性感染的关键抗生素.
- 常见的副作用包括长期使用时的血栓细胞减小和外围神经病变.
- 乳酸性酸是一种罕见但严重的药物不良反应,与linezolid相关.
研究的目的:
- 报告一个罕见的线化物诱导的乳酸性酸症 (LILA) 病例.
- 强调在出现不明原因代谢性酸性疾病的患者中考虑LILA的重要性.
- 强调LILA的诊断挑战和管理.
主要方法:
- 一个患有扩散多药耐药结核病的患者的病例报告.
- 临床表现包括吐,呼吸不全,低血压和高阴离子间隙代谢酸性化症.
- 排除其他原因,如败血症,酸性,功能障碍和毒性酒精摄入.
- 停止使用linezolid,并监测酸性疾病的解决.
主要成果:
- 患者出现了模仿败血症的症状,但没有可识别的感染.
- 实验室发现显示高离子间隙代谢酸性化,其他原因被排除.
- 停用线索利德导致乳酸性酸症的解决和临床改善.
- 建立了linezolid诱导的乳酸酸症的回顾性诊断.
结论:
- 莱涅佐利德诱导的乳酸酸症是一种罕见但至关重要的药物不良反应.
- 早期识别和停止使用线索利德对于患者的康复至关重要.
- 临床医生在排除其他原因后,应考虑在线索利德治疗未解释的乳酸症的患者中进行LILA治疗.
更多相关视频
09:34An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
1.8K
14:42Liquid Chromatography Coupled to Refractive Index or Mass Spectrometric Detection for Metabolite Profiling in Lysate-based Cell-free Systems
Published on: September 23, 2021
4.8K
相关概念视频
01:24Mania and Antimanic Drugs: Overview
181
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
181
01:24Muscle Recovery and Fatigue
2.1K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
2.1K
01:28Depolarizing Blockers: Mechanism of Action
1.6K
Depolarizing blockers act on skeletal muscle fibers' membranes and induce their depolarization. Most depolarizing blockers have two quaternary N+ atoms that bind the nicotinic acetylcholine receptors and cause neuromuscular blockade within minutes.
Succinylcholine is the most commonly used depolarizing blocker. Chemically, it constitutes two molecules of acetylcholine joined together by an acetate methyl group. They act on the receptors in the same way as acetylcholine. Because...
Succinylcholine is the most commonly used depolarizing blocker. Chemically, it constitutes two molecules of acetylcholine joined together by an acetate methyl group. They act on the receptors in the same way as acetylcholine. Because...
1.6K
00:56Crossed Aldol Reaction Using Strong Bases: Directed Aldol Reaction
2.2K
The reaction between two different carbonyl compounds comprising α hydrogen in the presence of a strong base like lithium diisopropylamide (LDA) to form a crossed aldol product is known as a directed aldol reaction. The directed aldol reaction is depicted in Figure 1.
2.2K
01:19Depolarizing Blockers: Pharmocokinetics
326
Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
326