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在COPD和健康对照中的下呼吸道微生物群

Solveig Tangedal^1,2, Rune Nielsen^3,2, Marianne Aanerud^3,2

¹Department of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway stangedal@gmail.com.

|February 8, 2024

概括

慢性阻塞性肺病 (COPD) 的下呼吸道微生物群不如健康个体那么多样化,吸烟对其的影响不同. 慢性肺炎严重程度和吸入性皮质类固醇 (ICS) 使用并没有显著改变下呼吸道微生物群.

科学领域:

微生物学微生物学
肺部病理学肺部病理学
基因组学就是基因组学.

背景情况:

在慢性阻塞性肺病 (COPD) 中,人们怀疑下呼吸道微生物群的改变.
关于吸烟,吸入性皮质类固醇 (ICS) 和COPD严重程度如何影响下呼吸道微生物群的数据有限.

研究的目的:

为了研究COPD患者和健康对照者之间的下呼吸道微生物群的差异.
探索吸烟,ICS使用和COPD严重程度对下呼吸道微生物组合的影响.

主要方法:

微型COPD研究分析了来自97名COPD患者和97名对照者的受保护的支气管支气管洗样本.
样品使用Illumina MiSeq进行测序,数据分析在QIIME 2和R.
通过问卷和临床测量收集了参与者的特征.

主要成果:

与对照组相比,在COPD患者中观察到较低的α-多样性 (均性和).
贝塔多样性与吸烟状态仅在COPD队列中不同.
九个属是差异丰富的,有富含COPD的Firmicutes;吸烟影响了对照中的种群丰富性,而Oribacterium在吸烟的COPD患者中缺席.

结论:

与对照组相比,COPD患者的下呼吸道微生物群不那么均,尽管同样丰富.
在COPD的气道中,Firmicutes类特别丰富.
吸烟对COPD患者和对照患者的微生物多样性和丰富性产生不同的影响,而COPD严重程度和ICS使用没有显著的关联.

关键词:

慢性肺炎病理学慢性肺炎病理学慢性慢性肺炎的流行病学呼吸道感染呼吸道感染

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