与心脏代谢疾病的发病率和发展轨迹相关的内脏脂肪:一项前性队列研究
Qida He1, Yu Wang1, Zhaolong Feng1
1Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou City, Jiangsu Province, PR China.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|February 8, 2024
概括
较高的内脏脂肪 (VAI) 增加了患第一个心脏代谢疾病 (FCMD) 和心脏代谢多病症 (CMM) 的风险. 然而,VAI可能会降低现有心脏代谢疾病的个体的死亡风险.
科学领域:
- 心血管研究研究心血管研究
- 代谢健康 代谢健康
- 肥胖问题研究研究
背景情况:
- 关于内脏脂肪组织对心脏代谢疾病发展和进展的影响的文献有限.
- 了解内脏脂肪在心脏代谢多病症 (CMM) 中的作用对于公共卫生至关重要.
研究的目的:
- 调查内脏脂肪和第一个心脏代谢疾病 (FCMD) 的发生率之间的联系.
- 检查内脏脂肪性对从FCMD到CMM的进展的影响.
- 评估内脏肥胖对所有原因的死亡率的影响,在有或没有心脏代谢疾病的个体中.
主要方法:
- 分析了来自423,934名参与者的英国生物库数据.
- 内脏脂肪指数 (VAI) 计算用于量化内脏脂肪.
- 多州模型用于分析疾病转变和死亡率,平均随访时间为13.5年.
主要成果:
- 高VAI显著增加了从健康转变为FCMD (HR 2.35) 和从FCMD转变为CMM (HR 1.64) 的风险.
- 内脏脂肪显示出与健康,FCMD和CMM状态 (HR 0.97) 的全因死亡率的中立关联.
结论:
- 内脏脂肪组织与FCMD和CMM的发展有关.
- 内脏脂肪可能在患有现有的心脏代谢疾病的患者中提供对所有原因死亡的保护作用.
- 针对高内脏脂肪和心脏代谢状况的个体进行有针对性的干预是有必要的.
更多相关视频
06:22Isolation of Viable Adipocytes and Stromal Vascular Fraction from Human Visceral Adipose Tissue Suitable for RNA Analysis and Macrophage Phenotyping
Published on: October 27, 2020
3.9K
06:56Author Spotlight: The Significance of Isolation, Culture, and Adipogenic Induction of SVF-Derived Preadipocytes from Mouse Perivascular Adipose Tissue
Published on: July 21, 2023
2.2K
相关概念视频
Cholesterol: Significance and Regulation
544
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
544
Obesity
503
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
503
Hypodermis
4.5K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
4.5K
