作为肺功能生物标志物的最大声调时间
Thaís Dias Feltrin1, Marcia da Silva Packaeser Gracioli1, Carla Aparecida Cielo1
1Federal University of Santa Maria, Santa Maria, RS, Brazil.
Journal of voice : official journal of the Voice Foundation
|February 8, 2024
概括
包括数值计数在内的最大发音时间可以作为慢性阻塞性肺病 (COPD) 患者肺功能受损的生物标志物. 这些声音测量,与自我评估的声音质量一起,表明疾病的严重程度.
科学领域:
- 肺部医学 肺部医学
- 语音语言病理学 语言病理学
- 生物标志物 生物标志物
背景情况:
- 慢性阻塞性肺病 (COPD) 显著影响呼吸功能.
- 声功能可能会受到COPD等全身性疾病的影响.
- 确定肺功能的非侵入性生物标志物对于患者管理至关重要.
研究的目的:
- 确定最大发声时间 (MPT) 是否是COPD患者强迫生命能力 (FVC) 的生物标志物.
- 为了描述COPD患者的声乐方面.
- 探索声乐参数与临床变量 (年龄,BMI,药物,症状,生活质量) 之间的相关性.
主要方法:
- 评估了25名COPD患者 (31-85岁) 的FVC,MPT (/a/),数值计数,语音症状尺度和语音生活质量.
- 使用描述性统计和推断测试 (学生的t,曼-惠特尼U).
- 使用ROC曲线分析;FVC<80%定义的肺功能障碍.
主要成果:
- 慢性肺炎患者的MPT (/a/),数值计数时间和数字数量减少.
- 在语音症状量表和语音生活质量分数中发现了显著的差异.
- 数字计数时间 ≤12.5秒建议受损的FVC.
结论:
- 慢性肺炎患者表现出声音偏差,包括减少MPT和数值计数障碍.
- 语音自我评价得分也显示了偏差.
- 特别是在数值计数期间,MPT是COPD肺功能障碍的潜在生物标志物.
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