相关实验视频

Updated: Jul 4, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

在土耳其人群中,IL-17F rs763780多态和牛皮风险的关联:一个病例对照研究

Ayşegül Başak Akadam-Teker¹, Burak Akşan²

¹Department of Medical Genetics, Giresun University, Faculty of Medicine, Giresun, Turkey.

Anais brasileiros de dermatologia

|February 8, 2024

概括

IL-17F rs763780变体,特别是C等位基因和TC/CC基因型,与患上牛皮的风险更高有关. 这一遗传因素在土耳其人群中具有重要意义.

科学领域:

遗传学遗传学是一个
免疫学免疫学免疫学
皮肤病学皮肤病学

背景情况:

牛皮是一种慢性炎症性疾病,影响皮肤和关节,遗传因素起着关键作用.
介素-17F (IL-17F) 基因与牛皮的免疫病原发生有关.

研究的目的:

在土耳其人群中调查IL-17F rs763780多态和牛皮易感性之间的关联.
为了确定IL-17F基因的变异是否会影响牛皮的风险和严重程度.

主要方法:

一项涉及201名牛皮患者和402名土耳其人口的健康对照的病例控制研究.
针对IL-17F rs763780多态的基因定型是使用TaqMan 5'基差别测试进行的.

主要成果:

在患者和对照组之间观察到IL-17F rs763780的基因型分布的统计学上显著差异.
与对照组 (10.2%和0.2%) 相比,TC和CC基因型在牛皮患者 (24.9%和2.0%) 中更为普遍.
患者的C等位基因显著更高 (p < 0.001),使得牛皮的风险增加了3.14倍.

结论:

在土耳其人群中,IL-17F rs763780多态,特别是C等位基因和TC/CC基因型,与牛皮风险增加有关.
需要使用更大的样本大小进行进一步的研究,以探索IL-17F在牛皮病原发生的作用.

关键词:

细胞因子 (cytokines) 是一种细胞因子.多态性多态性多态性牛皮是一种病.这种药物是因特莱基因-17F.

更多相关视频

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

相关概念视频

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

The JAK-STAT Signaling Pathway

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...