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Updated: Jul 4, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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针对性细胞外蛋白质降解由Dendronized DNA 嵌合体

Chenghong Zhu1, Weishan Wang1, Yan Wang1

  • 1State Key Laboratory of Analytical Chemistry for Life Sciences, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China.

ACS chemical biology
|February 8, 2024
PubMed
概括

研究人员开发了树化DNA仿真体 (DENTAC) 来降解引起疾病的细胞外蛋白质. 这种新的策略有效地准和去除像矩阵金属蛋白酶-9这样的蛋白质,提供了一种新的治疗方法.

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