一个基于ISATIN Schiff的新型复合物:合成,表征,抗菌活性和分子对接研究
Heba E Saad1, Gaber M Abu El-Reash2, Mohamed Gaber1
1Department of Chemistry, Faculty of Science, Tanta University, Tanta, 31527, Egypt.
BMC genomics
|February 8, 2024
概括
一个新的 (III) - - 斯基夫基复合物被合成和特征化. 这种复合物与其连接物相比显示出增强的抗微生物活性,显示出新的治疗剂的前景.
科学领域:
- 协调化学 协调化学
- 材料科学 材料科学 材料科学
- 抗菌研究 抗菌研究
背景情况:
- 来自伊沙和亚二醇衍生物的希夫基因因因其多样化的生物活性而闻名.
- 复合物正在被探索其潜在的治疗应用,包括抗菌性质.
研究的目的:
- 合成和描述一种新型的伊萨-希夫基联结体 (L2) 和其 (III) 复合体 (C2).
- 评估合成化合物的抗微生物和抗真菌潜力.
- 通过分子对接,研究连接体和复合体与真菌蛋白的结合亲和力.
主要方法:
- 通过异酸和2-氨基-5-甲基-1,3,4-亚二醇的反应合成异酸-希夫基联体 (L2).
- (III) - 施菲夫基复合物 (C2) 的水热合成.
- 使用光谱技术 (FT-IR,NMR,UV-vis,质谱),元素分析,TGA,HR-TEM和FE-SEM/EDX进行表征.
- 在体外对各种微生物进行抗菌活性测试.
- 使用MOE软件进行分子对接模拟,以评估蛋白质-配体相互作用.
主要成果:
- 新型的希夫基联体 (L2) 和其 (III) 复合体 (C2) 已成功合成并完全表征.
- 分子对接模拟表明,与连接物 (L2) 相比,复合物 (C2) 与*Fusarium oxysporum*的Avr2效应蛋白具有更强的结合亲和力.
- 实验室研究表明, (III) - 施菲基复合物 (C2) 显示出比自由配体 (L2) 具有更高的抗微生物和抗真菌活性.
结论:
- 合成的 (III) - 施菲基复合物代表了开发新抗菌剂的有希望的候选者.
- 复合物的增强生物活性归因于离子和希夫基结构的存在.
- 对这个复杂的治疗潜力的进一步研究是有必要的.
更多相关视频
相关概念视频
02:52Stereoisomerism
11.9K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
11.9K
02:34Structural Isomerism
19.2K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
19.2K