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阴道pH值可以影响对人类乳头瘤病毒感染的易感性

Yinxia Liu^1,2, Zhengyu Li^3,4

¹Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, No. 20 Section 3, Renmin South Road, Chengdu, Sichuan, 610041, People's Republic of China.

BMC infectious diseases

|February 8, 2024

概括

阴道pH值升高会增加对人类乳头瘤病毒 (HPV) 感染的易感性,因为它会影响病毒对细胞的粘附. 这一发现强调了pH值作为HPV感染风险的一个因素.

科学领域:

妇科妇科妇科妇科
病毒学病毒学
在瘤学瘤学.

背景情况:

宫癌是女性的主要癌症,主要是由持续高风险的人类乳头瘤病毒 (HPV) 感染引起的.
阴道pH值,通常保持在3.8-4.5之间在绝经前妇女,可以受到各种因素的影响.
以前的研究表明,阴道pH和HPV感染易感性之间存在联系.

研究的目的:

为了研究阴道pH值和对人类乳头瘤病毒 (HPV) 感染的易感性之间的关系.
在体外和体内探索pH值对HPV伪病毒 (PsVs) 感染的影响.

主要方法:

对3115名接受白血病检查的妇女的医疗数据进行了回顾性分析.
排除标准包括传染病,癌症,怀孕,最近的分娩和缺乏最近的HPV测试结果.
使用HPV伪病毒 (PsV) 进行体外和体内实验,以评估pH值对感染和病毒粘附的影响.

主要成果:

在阴道pH值≥5.0的女性中,与pH值<5.0的女性相比,观察到HPV和高风险HPV感染的比例更高.
试验室研究表明,在pH值较高的介质中,HPV PsVs感染率增加,主要是由于病毒对细胞的附着性增强.
在体内实验表明,随着pH值的增加,HPV PsVs对小鼠阴道上皮细胞的附着性更大.

结论:

阴道pH与HPV感染易感性有关.
pH通过影响病毒对细胞的附着性来影响HPVPsVs感染,无论是体外还是体内.
细胞表面受体Syndecan-1和Integrin α6似乎没有受到pH的影响,这表明其他机制需要进一步研究.

关键词:

在HPV中,HPV是HPV.这是一种HPV伪病毒.它们的pH值是pH值.

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