带有边际低出生体重的按期出生的儿童的精神疾病:一个基于人口的研究
Shu-I Wu1,2, Yu-Hsin Huang1,2, Kai-Liang Kao3
1Department of Medicine, MacKay Medical College, #46, Sec. 3, Zhongzheng Rd, Sanzhi Dist., New Taipei City, 252, Taiwan.
Child and adolescent psychiatry and mental health
|February 8, 2024
概括
带有边际低出生体重 (MLBW) 的按期出生的婴儿面临精神疾病的风险增加,包括ADHD和自闭症谱系障碍. 这凸显了对这些儿童集中精神健康和神经发育监测的需要.
科学领域:
- 围产期流行病学 围产期流行病学
- 儿童精神病学 儿童精神病学
- 神经发育障碍 神经发育障碍
背景情况:
- 边际低出生体重 (MLBW),定义为20002499g,已与各种神经和认知结果有关.
- 之前的研究还没有广泛探讨临床诊断的精神疾病,在按期出生的MLBW婴儿.
研究的目的:
- 为了调查与MLBW.W.确定的期满婴儿后期精神疾病的风险.
- 分析MLBW与特定精神病诊断的发生率之间的关联.
主要方法:
- 一项全国性的回顾性队列研究,利用台湾国家健康保险研究数据库 (2008年至2018年).
- 倾向性得分匹配被用来比较有或没有MLBW (≥2500g) 的按期出生的婴儿.
- 考克斯的比例危险分析评估了11种精神病诊断的发病率和危险比率,经过调整以考虑混因素.
主要成果:
- 该研究包括超过53,000名MLBW婴儿和130万名非MLBW婴儿.
- 按期出生的MLBW婴儿对注意力缺陷多动症 (HR=1.26),自闭症谱系障碍 (HR=1.26),行为障碍 (HR=1.25),情绪障碍 (HR=1.13) 和特定发育迟缓 (HR=1.38) 的风险显著增加.
结论:
- MLBW是发展后期精神疾病的重要危险因素,在按时出生的婴儿.
- 研究结果表明,有必要增加对患有MLBW的晚产儿精神健康和神经发育问题的关注.
- 在解释结果时,应考虑错误分类和残留混的可能性.
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