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Updated: Jul 4, 2025

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
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葡萄糖皮质类药物通过刺激巨细胞中克鲁佩尔类因子9的表达来增加脂肪

Yinliang Zhang1, Chunyuan Du1, Wei Wang2

  • 1Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Cellular Homeostasis and Disease, Tianjin Medical University, Tianjin, China.

Nature communications
|February 8, 2024
PubMed
概括

葡萄糖皮质类药物 (GCs) 通过激活巨细胞中的克鲁佩尔类因子9 (Klf9) 引起肥胖,从而使其失活,并破坏脂肪组织的平衡. 在髓状细胞中阻断Klf9可以防止GC诱导的肥胖.

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