新生儿大脑功能动态连接在期末和早产婴儿及其与早期儿童神经发育的关联
Lucas G S França1,2,3, Judit Ciarrusta1,2, Oliver Gale-Grant1,2
1Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.
Nature communications
|February 8, 2024
概括
大脑的动态功能连接是在出生时建立的. 过早出生婴儿的非典型模式与以后的行为差异有关,为早期神经发育和自闭症风险提供了见解.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 脑部成像 脑部成像
背景情况:
- 动态功能连接描述了改变的大脑区域的相互作用.
- 非典型的连接模式与神经发育状况 (如自闭症) 有关.
- 新生儿的动态功能连接的早期发展尚不清楚.
研究的目的:
- 描述出生后早期的动态功能连接.
- 为了比较到期和早产婴儿之间的连接模式.
- 调查早期动态连接和后来的行为结果之间的关联.
主要方法:
- 功能磁共振成像 (fMRI) 用于评估大脑连接.
- 从按期出生 (n=324) 和早产 (n=66) 婴儿收集数据.
- 行为评估 (Q-CHAT) 在18个月大时进行.
主要成果:
- 一个功能连接的动态景观,有六个短暂的状态,在出生时就存在.
- 过早出生的婴儿与满期出生的婴儿相比,表现出不典型的动态连接模式.
- 非典型的新生儿动态连接性与后来的非典型的社会,感官和重复性行为有关.
结论:
- 动态功能连接是在人类大脑发育的早期建立的.
- 过早分娩与早期大脑连接的改变有关.
- 早期的非典型连接性可以作为神经发育条件的生物标志物,包括自闭症.
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