具有多重重组合模式的Echovirus 25的F基因型一直在中国大陆持续和广泛传播
Xiaoyi Wang1,2, Jianping Cun3, Shikang Li4
1Medical School, Anhui University of Science and Technology, Huainan, 232001, China.
Scientific reports
|February 8, 2024
概括
埃科病毒25 (E25) 分子流行病学揭示了F基因型在中国的主导地位,由独特的重组模式和进化驱动. 这项研究增强了对E25预防和控制策略的理解.
科学领域:
- 病毒学 病毒学
- 分子流行病学分子流行病学
- 公共卫生 公共卫生
背景情况:
- 埃科病毒25 (E25) 是B型肠道病毒的一种,与无菌性脑膜炎,病毒性脑膜炎和急性性有关.
- 关于E25分子流行病学,进化和重组的系统研究很少.
- 了解E25的遗传多样性和传播对于疾病控制至关重要.
研究的目的:
- 在全球和中国调查埃科病毒25的分子流行病学,进化和重组.
- 为了确定E25的主导基因型和传播途径.
- 阐明导致E25流行的进化机制.
主要方法:
- 从全球E25菌株中对113个全长VP1序列进行了家族遗传分析.
- 通过HFMD监测网络在中国 (2009-2018) 隔离的E25菌株 (n=18) 的分析.
- 对E25序列进行了再组合和选择压力分析.
主要成果:
- 在全球范围内,E25菌株被分为9个基因型 (A-I),其中F基因型在中国大陆占主导地位.
- 对E25的平均核酸替代率为6.08 × 10-3替代/地点/年.
- 确定了17个重组模式,基因型F显示了9个不同的模式和其状蛋白中的阳性选择位.
结论:
- 基因型F在中国的主导地位可能与其多重重组合模式和进化特征有关.
- 已确定的传播途径和遗传多样性为E25预防和控制提供了基础.
- 这项研究为埃科病毒25的流行病学和演变提供了关键的见解.
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