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在健康的新生儿中,在第一个月内,肠道微生物组发展的共同轨迹具有有限的个体间环境变化

Xing-An Wang^1,2, Ju-Pi Li^1,3, Maw-Sheng Lee^2,4

¹Department of Pediatrics, Chung Shan Medical University Hospital, No. 110, Sec. 1, Chien-Kuo N. Road, Taichung, 402, Taiwan.

Scientific reports

|February 8, 2024

概括

婴儿的肠道微生物组在第一个月内形成了独特的结构,在第一个星期内发生了显著的转变. 外部环境因素,而不是与宿主相关的变量,主要影响这种早期肠道微生物的发展.

科学领域:

微生物学微生物学
新生儿健康新生儿健康
肠道微生物组研究研究

背景情况:

早期的肠道微生物组显著影响长期健康.
了解婴儿微生物发育对于健康干预至关重要.

研究的目的:

确定健康新生儿肠道微生物组的发育轨迹.
确定影响早期微生物社区结构的因素.

主要方法:

采集了28名新生儿的便样本,分别是24小时,7天和28天.
利用16S rRNA V3-V4区域的Illumina测序来分析微生物群的个人资料.

主要成果:

在每一个时间点观察到不同的肠道微生物群结构,在第一周出现了显著的转变.
蛋白质细菌在早期样本中占主导地位,而Firmicutes和Actinobacteria随着年龄的增长而增加.
产生的方式具有暂时的效果,但其他因素,如孕产妇的抗生素或光疗,其影响很小.

结论:

健康的新生儿在控制环境变化后的第一个月表现出一致的肠道微生物组发育轨迹.
外部环境因素在塑造生命早期的肠道微生物群中起着至关重要的作用.

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