皮层折叠与衰老和阿尔茨海默病的认知和CSF生物标志物相关
Fernanda Hansen P de Moraes1,2, Felipe Sudo3, Marina Carneiro Monteiro1
1Brain Connectivity Unit, D'Or Institute of Research and Education (IDOR), Rio de Janeiro, 225281-100, Brazil.
Scientific reports
|February 8, 2024
概括
一种新的皮层折叠测量方法有效地区分了阿尔茨海默病与健康的衰老. 这种结构生物标志物与脑脊液变化和认知衰退相关,为神经退行提供了洞察力.
科学领域:
- 神经成像是一种神经成像.
- 生物化学 生物化学
- 认知神经科学 认知神经科学
背景情况:
- 阿尔茨海默病 (AD) 诊断依赖于结构,生化和认知评估的组合.
- 现有的生物标志物可能无法完全捕捉AD的复杂演变.
- 基于哺乳动物皮层折叠的新型结构生物标志物被提议用于改善神经退行评估.
研究的目的:
- 量化和关联阿尔茨海默病的结构,生化和认知方面.
- 测试一种来自皮层折叠的新型结构生物标志物,以测试其在区分健康对照,轻度认知障碍和阿尔茨海默病患者中的区分能力.
- 探索这种皮层折叠生物标志物,脑脊液 (CSF) 生物标志物和认知衰退之间的关系.
主要方法:
- 从77名健康对照组,31名MCI患者和13名AD患者的T1w 3T MRI扫描进行了分析,使用FreeSurfer提取形态特征.
- 我们量化了皮层折叠变量,并使用最佳切点分析评估了它们的区分能力.
- 脑液生物标志物 (总Tau,Aβ40,Aβ42,Lipoxin) 和认知测试得分与MRI衍生的神经退行症测量结果相关.
主要成果:
- 皮层折叠在区分健康对照组和阿尔茨海默病患者方面表现出合理的准确性 (准确性=0.82).
- 皮层折叠还显示了健康对照组和轻度认知障碍组之间的区分能力 (准确率=0.56).
- 观察到全球神经退行测量,CSF生物标志物和认知评分之间的相关性,提供了健康,疾病和过渡状态的多方面的描述.
结论:
- 皮层折叠是阿尔茨海默病中神经退行症的一个有前途的结构生物标志物.
- 这种生物标志物与AD进展的关键生化和认知指标相关.
- 这些发现支持使用先进的形态分析来理解和潜在地诊断神经退行性疾病.
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